Assessment of a mathematical model considering the effect of flow rate on in-vitro drug-release from PLGA films

Drug-eluting stents implanted in blood vessels are subject to various dynamics of flow. In this study, we present the evaluation a mathematical model considering effect flow rate, simulate kinetic profiles drug release (Diclofenac Sodium (DS)) from in-vitro PLGA films. This solves set non-linear equation for modeling simultaneously burst, diffusion, swelling and erosion involved mechanisms liberation. The parameters depending on rate determined using corresponding equations. For proposed model, test data obtained our laboratory used. To quantify DS drug-carrier films, used flow-through cell apparatus closed-loop. Four values applied. each value, model-substance liberation kinetics showed an increase released with rate. simulated show good agreement experimental results. Therefore, use could provide practical tool assess polymer matrices under continuous constraint, help improve design eluting stents.